abstract：BACKGROUND:Portable monitoring is a convenient means for diagnosing sleep apnea. However, data on whether one night of monitoring is sufficiently precise for the diagnosis of sleep apnea are limited. RESEARCH QUESTION:The current study sought to determine the variability and misclassification in disease severity over ...

journal_title：Chest

authors： Punjabi NM,Patil S,Crainiceanu C,Aurora RN

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Early-life stress is becoming an important determinant of immune system programming. Maternal prenatal distress is found to be associated with atopic disease in offspring but the separate effects of postnatal distress are not well-studied. RESEARCH QUESTION:Does the likelihood of asthma and atopic dermatiti...

journal_title：Chest

authors： van der Leek AP,Bahreinian S,Chartier M,Dahl ME,Azad MB,Brownell MD,Kozyrskyj AL

更新日期：2020-07-01 00:00:00

abstract：:We report the clinical history, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in a neonate whose mother was also a patient. The newborn was the youngest patient with COVID-19 in the world at the time he was diagnosed. This case has brought more attention and understanding to the epid...

journal_title：Chest

authors： Xiong Y,Zhang Q,Zhao L,Shao J,Zhu W

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Lung cancer screening, despite its proven mortality benefit, remains vastly underutilized. Previous studies examined knowledge, attitudes, and beliefs to better understand the reasons underlying the low screening rates. These investigations may have limited generalizability because of traditional participant...

journal_title：Chest

authors： Monu J,Triplette M,Wood DE,Wolff EM,Lavallee DC,Flum DR,Farjah F

更新日期：2020-07-01 00:00:00

abstract：:Considerable heterogeneity persists in the conduct and reporting of statistical analyses in the medical literature. Authors submitting manuscripts to CHEST are encouraged to adhere to the following guidelines where possible. ...

journal_title：Chest

authors： Kattan MW,Vickers AJ

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:We recently showed that administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep greatly reduced OSA severity, likely by increasing upper airway dilator muscle activity during sleep. In patients with OSA who performed the ato-oxy tria...

journal_title：Chest

authors： Taranto-Montemurro L,Messineo L,Azarbarzin A,Vena D,Hess LB,Calianese NA,White DP,Wellman A,Sands SA

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:In addition to affecting the oxygen supply to the brain, pulmonary function is a marker of multiple insults throughout life (including smoking, illness, and socioeconomic deprivation). In this meta-analysis of existing longitudinal studies, the hypothesis that lower pulmonary function and respiratory illness...

journal_title：Chest

authors： Russ TC,Kivimäki M,Batty GD

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Adjunctive strategies are an important part of the management of ARDS. However, their application in clinical practice remains inconsistent. RESEARCH QUESTION:We wished to determine the frequency and patterns of use of adjunctive strategies in patients with moderate to severe ARDS (Pao2/Fio2 [P/F ratio] < 1...

journal_title：Chest

authors： Duggal A,Rezoagli E,Pham T,McNicholas BA,Fan E,Bellani G,Rubenfeld G,Pesenti AM,Laffey JG,LUNG SAFE Investigators and the ESICM Trials Group.

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The risk stratification value of the 6-min walk test (6MWT) to decide the feasibility of surgical resection is not well elucidated in patients with non-small cell lung cancer (NSCLC) and moderately decreased lung function. OBJECTIVE:This study aimed to determine the role of the 6MWT in predicting postoperat...

journal_title：Chest

authors： Lee H,Kim HK,Kang D,Kong S,Lee JK,Lee G,Shin S,Cho J,Zo JI,Shim YM,Park HY

更新日期：2020-06-01 00:00:00

abstract：:Parasitoses are infectious diseases of global distribution, with predominance in areas of poor sanitation. Parasites cause damage through direct tissue injury and the inflammatory response generated by their migration and establishment in various organs. Thoracic involvement by parasitic disease can generate both spec...

journal_title：Chest

authors： Fiorentini LF,Bergo P,Meirelles GSP,Capobianco J,Mohammed TL,Verma N,Marchiori E,Irion KL,Hochhegger B

更新日期：2020-05-01 00:00:00

abstract：CASE PRESENTATION:A 75-year-old man was referred to our institution for worsening dyspnea, decreased activity tolerance, myalgias, and an increase in oxygen requirement. Nine months before the initial referral, the patient presented to an outside hospital for acute hypoxemic respiratory failure requiring a right-sided ...

journal_title：Chest

authors： Tseng S,Olson K,Shamsid-Deen N,Savajiyani S,Sista R,Hodges T,Saggar R

更新日期：2020-05-01 00:00:00

abstract：:Sleep health is a multidimensional construct that includes adequate duration, quality, and appropriately timed sleep that may be influenced by environmental factors. In this review, we focus on how an individual's living and sleeping environment, both the surrounding neighborhood physical and social features and the a...

journal_title：Chest

authors： Billings ME,Hale L,Johnson DA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The long-term clinical course of asthma in patients with eosinophilic granulomatosis with polyangiitis (EGPA) remains unclear. We aimed to characterize long-term asthma in EGPA and to identify baseline predictors of long-term asthma severity. METHODS:This retrospective cohort study included patients who ful...

journal_title：Chest

authors： Berti A,Cornec D,Casal Moura M,Smyth RJ,Dagna L,Specks U,Keogh KA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Signs of both motor and sensory nervous lesions have previously been shown in the upper airway of patients with OSA and habitual snorers. Snoring per se may damage all upper airway neurons over time, thereby causing progression to manifest sleep apnea. To test this hypothesis, nonsnoring subjects, untreated ...

journal_title：Chest

authors： Svanborg E,Ulander M,Broström A,Sunnergren O

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:High-resolution chest CT (HRCT) scan is recommended after pulmonary arteriovenous malformation (PAVM) embolotherapy to assess for PAVM persistence and untreated PAVM growth. Graded transthoracic contrast echocardiography (TTCE) predicts the need for embolotherapy in PAVM screening. This study sought to deter...

journal_title：Chest

authors： DePietro DM,Curnes NR,Chittams J,Ferrari VA,Pyeritz RE,Trerotola SO

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Each year, > 1.5 million Americans are diagnosed with an incidentally detected lung nodule. Practice guidelines attempt to balance the benefit of early detection of lung cancer with the risks of diagnostic testing, but adherence to guidelines is low. The goal of this study was to determine guideline adherenc...

journal_title：Chest

authors： Verdial FC,Madtes DK,Cheng GS,Pipavath S,Kim R,Hubbard JJ,Zadworny M,Wood DE,Farjah F

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Lung cancer screening (LCS) is an important secondary prevention measure to reduce lung cancer mortality. The goal of this study was to assess state-level variations in LCS among the US elderly during the first 3 years since Medicare began its LCS reimbursement policy in 2015. METHODS:This ecological study ...

journal_title：Chest

authors： Liu B,Dharmarajan K,Henschke CI,Taioli E

更新日期：2020-04-01 00:00:00

abstract：CASE PRESENTATION:A 62-year-old woman with a history of partially treated Graves disease and hypertension presented with approximately 3 weeks of worsening fatigue, lower extremity myalgias, and shortness of breath. Her medical history included a thyroid radiofrequency ablation several years earlier. Following the abla...

journal_title：Chest

authors： Park BD,Lyn-Kew K,Granchelli A,Mehta A

更新日期：2020-03-01 00:00:00

abstract：:Bronchoscopy is essential to the practice of pulmonary medicine. It is an important diagnostic and therapeutic tool for many disease processes. Bronchoscopy can be performed in a variety of clinical settings, from the bedside to an operating room. Although bronchoscopy has been practiced for more than a century, conse...

journal_title：Chest

authors： Mehta AC,Avasarala SK,Jain P,Deshwal H,Gildea TR

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:There remains debate over the best invasive diagnostic modality for mediastinal nodal evaluation. Prior studies have limited generalizability and insufficient power to detect differences in rare adverse events. We compared the risks and costs of endobronchial ultrasound (EBUS)-guided nodal aspiration and med...

journal_title：Chest

authors： Verdial FC,Berfield KS,Wood DE,Mulligan MS,Roth JA,Francis DO,Farjah F

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Thoracentesis can be accomplished by active aspiration or drainage with gravity. This trial investigated whether gravity drainage could protect against negative pressure-related complications such as chest discomfort, re-expansion pulmonary edema, or pneumothorax compared with active aspiration. METHODS:Thi...

journal_title：Chest

authors： Lentz RJ,Shojaee S,Grosu HB,Rickman OB,Roller L,Pannu JK,DePew ZS,Debiane LG,Cicenia JC,Akulian J,Walston C,Sanchez TM,Davidson KR,Jagan N,Ahmad S,Gilbert C,Huggins JT,Chen H,Light RW,Yarmus L,Feller-Kopman D,Le

更新日期：2020-03-01 00:00:00

abstract：CASE PRESENTATION:A 72-year-old man presented to our ED less than 24 hours following the acute onset of nausea, vomiting, and diarrhea. Within 12 hours of symptom onset, he noted bilateral lower extremity pain and swelling. His pain was associated with a new violaceous irregular rash on the anterior aspect of both feet...

journal_title：Chest

authors： Gittens AT,Clarke JD,Abdelbaki S,Kwon JS

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The occurrence of catamenial pneumothorax (CP) is rare, and the awareness of this diagnosis among physicians is insufficient. CP is highly correlated with pelvic endometriosis and remains the most common form of thoracic endometriosis syndrome. Circulating endometrial cells (CECs) have been previously detect...

journal_title：Chest

authors： Kiss I,Pospisilova E,Kolostova K,Maly V,Stanek I,Lischke R,Schutzner J,Pawlak I,Bobek V

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Substance P and the neurokinin-1 (NK-1) receptor are implicated in chronic refractory cough pathophysiology. We assessed the efficacy and safety of orvepitant, a brain-penetrant NK-1 antagonist, in an open-label study in CRC patients with chronic refractory cough. METHODS:Thirteen patients with daytime coug...

journal_title：Chest

authors： Smith J,Allman D,Badri H,Miller R,Morris J,Satia I,Wood A,K Trower M

更新日期：2020-01-01 00:00:00

abstract：CASE PRESENTATION:A 78-year-old man with asthma and COPD presented with shortness of breath, cough, and severe malaise for 4 days. Upon arrival, the patient was conscious and body temperature was 37.5°C. Arterial oxygen saturation (Spo2) was 80% on room air. Laboratory data demonstrated a WBC count of 17,400/μL (89.5% ...

journal_title：Chest

authors： Nakamatsu E,Morita T,Morishima A,Tagawa H,Furukawa M,Matsushita M,Yamane H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Early appropriate diagnosis of acute heart failure (AHF) is recommended by international guidelines. This study assessed the value of several lung ultrasound (LUS) strategies for identifying AHF in the ED. METHODS:This prospective study, conducted in four EDs, included patients with diagnostic uncertainty b...

journal_title：Chest

authors： Buessler A,Chouihed T,Duarte K,Bassand A,Huot-Marchand M,Gottwalles Y,Pénine A,André E,Nace L,Jaeger D,Kobayashi M,Coiro S,Rossignol P,Girerd N

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical illness causes endothelial dysfunction and lung injury in experimental models. This study hypothesized that elevated plasma mtDNA is associated with ARD...

journal_title：Chest

authors： Faust HE,Reilly JP,Anderson BJ,Ittner CAG,Forker CM,Zhang P,Weaver BA,Holena DN,Lanken PN,Christie JD,Meyer NJ,Mangalmurti NS,Shashaty MGS

更新日期：2020-01-01 00:00:00

abstract：CASE PRESENTATION:A man in his 20s presented to the ED after several months of progressive dyspnea, dry cough, and night sweats. He had no chest pain, fevers, weight loss, or sick contacts. He was previously healthy and took no medications. Social history was notable for 5 pack-years of tobacco use. The patient was sex...

journal_title：Chest

authors： Sonnick MA,Weisman S,Borczuk AC,Turetz ML

更新日期：2019-12-01 00:00:00

abstract：:Because of an emphasis on patient safety and recognition of the effectiveness of simulation as an educational modality across multiple medical specialties, use of health-care simulation (HCS) for medical education has become more prevalent. In this article, the effectiveness of simulation for areas important to the pr...

journal_title：Chest

authors： Seam N,Lee AJ,Vennero M,Emlet L

更新日期：2019-12-01 00:00:00

abstract：:Burnout syndrome is an increasingly common phenomenon that threatens our critical care workforce and the well-being of its members. Burnout syndrome can be conceived of as a workforce manifestation of chronic workload and workforce capacity imbalance. This study explores the role of workload management tools that can ...

journal_title：Chest

authors： Lilly CM,Cucchi E,Marshall N,Katz A

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:When evaluating peripheral pulmonary lesions, a 3.0-mm ultrathin bronchoscope (UTB) with a 1.7-mm working channel is advantageous regarding good access to the peripheral airway, whereas a 4.0-mm thin bronchoscope provides a larger 2.0-mm working channel, which allows the use of various instruments including ...

journal_title：Chest

authors： Oki M,Saka H,Asano F,Kitagawa C,Kogure Y,Tsuzuku A,Ando M

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Fibrotic interstitial lung diseases (ILDs) are highly morbid chronic disorders that frequently occur in working age individuals. The goal of this study was to determine workplace productivity loss, its determinants, and its estimated costs in patients with fibrotic ILD. METHODS:Patients with idiopathic pulm...

journal_title：Chest

authors： Algamdi M,Sadatsafavi M,Fisher JH,Morisset J,Johannson KA,Fell CD,Kolb M,Manganas H,Cox G,Gershon AS,Halayko AJ,Hambly N,Khalil N,Shapera S,To T,Wilcox PG,Guler S,Ryerson CJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Shared decision-making is an essential element of low-dose CT (LDCT) screening for lung cancer. Understanding patient-level outcomes from the National Lung Screening Trial (NLST) is critical to effectively communicate risks and benefits of screening to patients. METHODS:We performed a secondary analysis of ...

journal_title：Chest

authors： Iaccarino JM,Silvestri GA,Wiener RS

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Postnasal drip (PND) is a common symptom associated with upper respiratory tract disorders. It occurs without other symptoms or combined with chronic rhinosinusitis. However, the pathophysiology of PND is debated to this day, and an objective definition of PND has not been established. Therefore, we aimed to...

journal_title：Chest

authors： Bucher S,Schmid-Grendelmeier P,Soyka MB

更新日期：2019-10-01 00:00:00

abstract：:Hospitalizations for patients with acute exacerbations of COPD are associated with several adverse patient outcomes as well as with significant health-care costs. Despite many interventions targeted at reducing readmissions following an initial hospitalization, there are few strategies that have been consistently asso...

journal_title：Chest

authors： Freedman N

更新日期：2019-10-01 00:00:00

abstract：CASE PRESENTATION:A 72-year-old man underwent endoscopic resection of a 10-mm polypoid sessile lesion of the rectum. Histologic examination found a well-differentiated, low-grade (G1), neuroendocrine tumor. A thoracoabdominal CT scan was performed for staging purposes. The chest CT scan revealed a so-called cannonball-...

journal_title：Chest

authors： Scamporlino A,Mengoli MC,Calabrese O,Della Casa G,Aramini B,Spallanzani A,Morandi U,Stefani A

更新日期：2019-10-01 00:00:00

abstract：:Point-of-care ultrasonography is a key skill for the critical care clinician and is gaining widespread acceptance by clinicians in all areas of medicine. In addition to mastery of image acquisition, image interpretation, and clinical application, intensivists need to be adept with billing for their scanning activity. ...

journal_title：Chest

authors： Koenig SJ,Lou BX,Moskowitz Y,Narasimhan M,Mayo PH

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries...

journal_title：Chest

authors： Sator L,Horner A,Studnicka M,Lamprecht B,Kaiser B,McBurnie MA,Buist AS,Gnatiuc L,Mannino DM,Janson C,Bateman ED,Burney P,BOLD Collaborative Research Group.

更新日期：2019-08-01 00:00:00

abstract：CASE PRESENTATION:A 37-year-old man with poorly controlled type 2 diabetes presented with severe right-sided pleuritic chest pain, respiratory splinting, and cough. Two weeks earlier, he had been evaluated at an urgent care for cough and was prescribed a 5-day course of azithromycin for bronchitis. He then presented to...

journal_title：Chest

authors： Galant-Swafford J,Light M,Onaitis MW,Rawlings SA,Fierer J,Landsberg JW

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Characterizing acute exacerbations of COPD (AECOPD) and individualizing therapy is challenging. Key exacerbation therapies include antibiotics and systemic corticosteroids. Blood eosinophils, when either low or high, may offer a simple, inexpensive distinction to predict beneficial responses to these therapi...

journal_title：Chest

authors： MacDonald MI,Osadnik CR,Bulfin L,Hamza K,Leong P,Wong A,King PT,Bardin PG

更新日期：2019-07-01 00:00:00